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ea0032p624 | Growth hormome IGF axis – basic | ECE2013

Association between a common GH receptor polymorphism (exon 3-deletion), pre- and postnatal growth, serum insulin-like growth factor 1 and reproductive function in 838 healthy young males

Andreassen Mikkel , Beck Jensen Rikke , Jorgensen Niels , Juul Anders

Introduction: A common genetic polymorphism in the GH receptor (GHR) is deletion of the entire exon 3 sequence (GHRd3 isoform). The GHRd3 isoform seems to be more sensitive with increased downstream GH signalling in activated exon 3 deleted receptor dimers (GHRd3/d3) compared to full length receptor dimers (GHRfl/fl). Presence of the GHRd3 isoform might be associated to pre- and postnatal growth and pubertal development in boys, although controversy exists. The aim was to inve...

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Association between a common GH receptor polymorphism (exon 3-deletion), pre- and postnatal growth, serum insulin-like growth factor 1 and reproductive function in 838 healthy young males

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